Table 2. HDACs Inhibitory Profiles of 10a, 10c, and 10f.
| IC50 (nM)a |
||||
|---|---|---|---|---|
| HDAC isoform | 10a | 10c | 10f | SAHA |
| HDAC1 | 194 ± 13 | 959 ± 206 | 111 ± 30 | 46 ± 1 |
| HDAC2 | 249 ± 6 | 277 ± 17 | 203 ± 14 | 120 ± 7 |
| HDAC3 | 126 ± 13 | 235 ± 33 | 96 ± 16 | 35 ± 1 |
| HDAC4 | >100000 | >100000 | 27000 ± 6000 | >100000 |
| HDAC5 | 4600 ± 400 | 14900 ± 1700 | 4600 ± 600 | 41500 ± 10000 |
| HDAC6 | 9.7 ± 0.6 | 4.4 ± 0.4 | 7.6 ± 0.8 | 39.9 ± 9 |
| HDAC7 | 6000 ± 200 | >100000 | 8800 ± 1300 | 41800 ± 500 |
| HDAC8 | 6700 ± 700 | >100000 | 3600 ± 100 | 1800 ± 300 |
| HDAC9 | 9100 ± 800 | >100000 | 15200 ± 2900 | 64000 ± 8100 |
| HDAC10 | 268 ± 23 | 164 ± 10 | 114 ± 26 | 80 ± 8 |
| HDAC11 | >100000 | >100000 | >100000 | 40000 ± 3000 |
a
Assays were performed in replicate (n ≥ 2).