Table 3. Antiproliferative Activities of 10a, 10c, and 10f.
IC50 (μM)a |
|||||
---|---|---|---|---|---|
compd | K562 | HL-60 | RPMI-8226 | HCT-116 | A549 |
10a | 0.69 ± 0.21 | 0.34 ± 0.05 | 0.36 ± 0.06 | 1.25 ± 0.07 | 5.86 ± 0.34 |
10c | 0.49 ± 0.10 | 0.25 ± 0.01 | 0.23 ± 0.04 | 0.83 ± 0.03 | 0.79 ± 0.07 |
10f | 0.83 ± 0.13 | 0.61 ± 0.03 | 0.64 ± 0.06 | 2.25 ± 0.12 | 9.45 ± 1.07 |
SAHA | 1.45 ± 0.13 | 0.52 ± 0.08 | 0.57 ± 0.06 | 1.81 ± 0.17 | 2.42 ± 0.02 |
IC50 values are expressed as the mean ± standard deviation of three separate determinations.