Table 7.

Effect sizes for studies comparing SSRI versus no SSRI interventions.

Name	Size	SSRI	Effect size: SMD [95% CI]
SSRI vs CBT
Asbahr et al. (27)	40	Sertraline	0.34 [-0.28, 0.97]
POTS (4)	56	Sertraline	0.27 [-0.26, 0.79]
Skarphedinsson et al. (18)	50	Sertraline	-0.25 [-0.81, 0.31]
SSRI + CBT vs CBT
POTS (4)	56	Sertraline	-0.30 [-0.83, 0.22]
Storch et al. (24)	33*	Sertraline, titrated	0.22 [-0.47, 0.90]
Storch et al. (24)	30*	Sertraline, regular	-0.02 [-0.74, 0.69]
SSRI vs Placebo
Geller et al. (30)	103	Fluoxetine	-0.49 [-0.91, -0.07]
Geller et al. (31)	203	Paroxetine	-0.42 [-0.70, -0.15]
Liebowitz et al. (29)	43	Fluoxetine	-0.28 [-0.89, 0.32]
March and Friesen (32)	187	Sertraline	-0.42 [-0.71, -0.13]
POTS (4)	56	Sertraline	-0.66 [-1.20, -0.12]
Riddle et al. (25)	14	Fluoxetine	-0.75 [-1.89, 0.39]
Riddle et al. (33)	120	Fluvoxamine	-0.36 [-0.72, 0.00]
SSRI + CBT vs Placebo
POTS (4)	56	Sertraline	-1.41 [-2.00, -0.82]

*These represent summation of arms (SSRI + placebo) and both share the same placebo control group (i.e. 14 + 16 and 17 + 16).