Table 2.
Multivariable fractional polynomial functions and logarithm hazard ratios for breast cancer-specific survival using all variables
| Variables | Function | logHR | P value |
|---|---|---|---|
| Continuous variables | |||
| Age1 | (age/100)−0.5 | − 10.87 | 0.0035 |
| Age2 | (age/100)−0.5 × log(age/100) | 8.968 | < 0.001 |
| Tumor size, mm | log(size/10) | 0.7678 | < 0.001 |
| Node-positive ratio | ((ratio + 0.1)/0.1)0.5 | 0.5339 | < 0.001 |
| Categorical variables | |||
| Chemotherapy | |||
| Without | – | – | – |
| With | – | − 0.4147 | < 0.001 |
| Radiotherapy | |||
| Without | – | – | – |
| With | – | − 0.3203 | < 0.001 |
| Grade | |||
| 1 | – | – | – |
| 2 | – | 0.4795 | 0.015 |
| 3 | – | 0.818 | < 0.001 |
| Subtype | |||
| Luminal-like | – | – | – |
| HER2 | – | 0.1806 | 0.22 |
| Triple negative | – | 0.6457 | < 0.001 |
| Pathological stage | |||
| 1 | – | – | – |
| 2 | – | 0.5311 | < 0.001 |
| 3 | – | 1.134 | < 0.001 |
| 4 | – | 2.172 | < 0.001 |
| Targeted therapy | |||
| Without | – | – | – |
| With | – | − 0.4687 | 0.001 |
| Hormone/steroid therapy | |||
| Without | – | – | – |
| With | – | − 0.8397 | < 0.001 |
| Lymph vessel or vascular invasion (LVI) | |||
| No | – | – | – |
| Yes | – | 0.3321 | < 0.001 |
Derived from model 2