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Therapeutic efficacy of M-PHMs/miR-124 in vivo. Left ankle thickness (A) and clinical score of AIA rats (B) treated with various drug formulations were obtained (*P < 0.05, **P < 0.01, ***P < 0.001, PHMs/miR-124, PHMs/miR-124 NC, and MTX separately compared with M-PHMs/miR-124). (C) Photographs of hind paws and representative X-ray of the left ankle (D) from AIA rats treated with various drug formulations. Rats without AIA were set as normal group. Values are mean ± SEM (n=6).
