Figure 2.

Volumetric analysis of the blood-brain barrier opening from the contrast-enhanced T1-weighted MR coronal images. The volumes of the transgenic animals were at the order of 54.8 ± 2.02 mm³, 52.46 ± 6.59 mm³, 54.22 ± 7.44 mm³ and 52.5 ± 5.64 mm³, while 52,83 ± 8.81 mm³, 54.98 ± 5.97 mm³, 55.48 ± 3.75 mm³and 54.49 ± 9.76 mm³ of the wild-type mice for the four consecutive weeks. Longitudinal analysis did not show any significant difference across weeks. Additionally, the opening volumes did not differ between transgenic and wild-type animals within the same week interval.