TABLE 1.

Variable positions in OMPs sequence related to pathotype or AIEC phenotypic characteristics are depicted.

		All strains			Adhesion index		Invasion index
Variable position	Amino acid	Non-AIEC (n = 30)	AIEC (n = 14)	p-value	Bacteria/cell	p-value	% *	p-value
OmpA
200	A	80.0%	42.9%	0.018	4.1 ± 7.4	0.044	0.184 ± 0.457	0.084
	V	20.0%	57.1%		7.8 ± 7.9		0.224 ± 0.359
OmpC
232	D	62.1%	85.7%	0.108	6.5 ± 8.0	0.017	0.229 ± 0.474	0.002
	A	37.9%	14.3%		2.9 ± 6.5		0.060 ± 0.157
231	W	31.0%	64.3%	0.041	6.4 ± 8.1	0.189	0.315 ± 0.589	0.058
	D	69.0%	35.7%		4.6 ± 7.5		0.079 ± 0.158
89	S	31.0%	64.3%	0.041	6.4 ± 8.1	0.372	0.314 ± 0.589	0.109
	N	69.0%	35.7%		4.7 ± 7.4		0.080 ±0.158
220	V	20.7%	57.1%	0.022	7.9 ± 8.6	0.078	0.366 ±0.653	0.022
	I	79.3%	42.9%		4.2 ± 7.0		0.087 ± 0.169
OmpF
51	E	80.0%	100.0%	0.084	6.1 ± 7.9	0.040	0.198 ± 0.433	0.322
	V	20.0%	0.0%		0.2 ± 0.4		0.021 ± 0.019
60	M	80.0%	100.0%	0.084	6.1 ± 7.9	0.040	0.198 ± 0.433	0.322
	K	20.0%	0.0%		0.2 ± 0.4		0.021 ± 0.019

In bold statistically significant comparisons are indicated. For each position, the first amino acid presented is the one present in the LF82 reference strain. Adhesion and invasion indices were obtained from raw data in Supplementary Table S1. ^*Percentage of intracellular bacteria after 1 h gentamicin treatment relative to the inoculum.