Figure 4.

Constructed protein-protein interaction network for the differentially expressed genes. A. The network included interactions between all of the differential expressed genes. The size of the dots reflects the between centrality of the gene within the network. MCM3, MCM4 and E2F1 which were genes in cell cycle pathway observed within the module in the core of the network. B. Some genes with similar function were clustered into 17 modules. And the modules were divided into four categories according to their biological functions as follows: cell cycle, signal pathway, metabolism of biological macromolecules and autophagy, then marked with green, yellow, blue and purple, respectively.