Table 2.

Multivariate analysis of risk factors related to overall survival and progression-free survival in BCLC stage 0-B HBV-related HCC patients

Variable	Overall Survival				Progression-free Survival
	HR	95%CI	P		HR	95%CI	P
Gender
Male	1				1
Female	0.617	0.426-0.895	0.011		0.728	0.558-0.950	0.019
Smoking
Non-smoker	----				1
Smoker	----	----	----		1.289	1.054-1.577	0.014
HBV-DNA(IU/ml)
Low≤500	1				1
High>500	1.472	1.121-1.933	0.005		1.537	1.274-1.855	<0.0001
Tumor multiplicity
Solitary	1				1
Multiple	1.55	1.188-2.024	0.001		1.369	1.132-1.657	0.001
Tumor size(cm)
≤5	1				----
>5	2.636	1.995-3.484	<0.0001		----	----	----
HGB(g/L)
Low≤120	1				1
High>120	0.638	0.483-0.843	0.002		0.609	0.498-0.743	<0.0001
AFP(ng/ml)
Low≤400	1				1
High>400	2.235	1.696-2.947	<0.0001		1.971	1.605-2.420	<0.0001

HGB, haemoglobin; AFP, alpha-fetoprotein; Cox proportional hazards model;

P < 0.05 was considered as statistically significant.