Table 3.

Multivariate analysis of risk factors related to overall survival and progression-free survival in BCLC stage C-D HBV related HCC patients

Variable	Overall Survival				Progression-free Survival
	HR	95%CI	P		HR	95%CI	P
HBV-DNA( IU/ml)
Low≤500	1				----
High>500	1.284	1.001-1.646	0.049		----	----	----
PVTT at baseline
Yes	1				1
No	1.49	1.135-1.956	0.004		1.37	1.104-1.699	0.004
HGB(g/L)
Low≤120	1				----
High>120	0.702	0.548-0.899	0.005		----	----	----
PLT (109/L)
Low≤100	1				1
High>100	1.739	1.358-2.227	<0.0001		1.452	1.190-1.772	<0.0001
TBIL(μmol/L)
Normal≤18.8	1				----
High>18.8	1.397	1.058-1.845	0.018		----	----	----
ALT (U/L)
Normal ≤50	----				1
High>50	----	----	----		1.317	1.083-1.601	0.006
AFP(ng/ml)
Low≤400	1				1
High>400	1.591	1.236-2.048	<0.0001		2.141	1.743-2.629	<0.0001

PVTT, portal vein tumor thrombus; HGB, haemoglobin; PLT, platelet; ALT, alanine aminotransferase; TBIL, totall bilirubin; AFP, alpha-fetoprotein; Cox proportional hazards model; P < 0.05 was considered as statistically significant.