Table 4.

Multivariate analysis of risk factors related to overall survival for female and male in BCLC stage 0-B HBV-related HCC patients

	Overall Survival in female					Overall Survival in male
	Univariate analysis			Multivariate analysis		Univariate analysis			Multivariate analysis
Variables	HR	95%CI	P values	Hazard Ratio for Death (95%CI)		HR	95%CI	P values	Hazard Ratio for Death (95%CI)
Age(y)	1.14	0.40-3.23	0.81			0.98	0.72-1.32	0.87
≤50
>50
Smoking	0.63	0.09-4.59	0.65			1.17	0.88-1.55	0.29
Non-smoker
Smoker
Alcohol	2.85	0.68-11.87	0.15			1.27	0.95-1.68	0.1
No alcohol
Alcohol
HBV-DNA(IU/ml)	2.15	1.10-4.20	0.025			1.81	1.36-2.42	<0.0001	1.44(1.07-1.94)
Low≤500
High>500
HBeAg at baseline	1.33	0.67-2.65	0.41			1.01	0.79-1.46	0.64
Negative
Positive
Tumor multiplicity	2.5	1.29-4.84	0.007	2.06(1.05-4.07)		1.87	1.41-2.49	<0.0001	1.48(1.11-1.98)
Solitary
Multiple
Tumor size(cm)	3.97	1.98-7.98	<0.0001	3.37(1.65-6.89)		3.25	2.42-4.35	<0.0001	2.47(1.83-3.34)
≤5
>5
PVTT at baseline	0.049	0.00-647825.1	0.719			3.03	0.97-9.45	0.057
Yes
No
Cirrhosis	0.66	0.20-2.14	0.48			1.25	0.74-2.12	0.41
Yes
No
WBC (109/L)	1.75	0.90-3.39	0.098			1.002	0.75-1.35	0.99
Low≤4
High>4
HGB(g/L)	0.64	0.33-1.26	0.2			0.502	0.37-0.67	<0.0001	0.61(0.45-0.82)
Low≤120
High>120
PLT (109/L)	1.4	0.72-2.73	0.33			1.14	0.85-1.51	0.39
Low≤100
High>100
ALT (U/L)	1.63	0.76-3.47	0.21			1.52	1.13-2.04	0.006
Normal ≤50
High>50
TBIL(μmol/L)	1.65	0.85-3.20	0.14			1.64	1.24-2.19	0.001	1.4(1.05-1.88)
Normal≤18.8
High>18.8
ALB(g/L)	0.46	0.19-1.12	0.09			0.58	0.42-0.80	0.001
Normal≤40
High>40
PTA(%)	1.01	0.47-2.15	0.99			0.59	0.44-0.79	0.001
Low≤70
High>70
AFP(ng/ml)	1.08	0.49-2.38	0.85			3.06	2.28-4.10	<0.0001	2.63(1.95-3.54)
Low≤400
High>400

PVTT, portal vein tumor thrombus; WBC, white blood cell; HGB, haemoglobin; PLT, platelet; AFP, alpha-fetoprotein; ALT, alanine aminotransferase; TBIL, totall bilirubin; ALB, albumin; PTA, prothrombin time activity; Cox proportional hazards model; P < 0.05 was considered as statistically significant.