Table 1.
Clinicopathological characteristics of high-grade LCNEC and SCLC patients
| LCNEC N=1223 (%) |
SCLC N=18182 (%) |
P valuea | |
|---|---|---|---|
| Age | 0.001 | ||
| <60 | 347 (28.4) | 4528 (24.9) | |
| 60-79 | 431 (35.2) | 6138 (33.8) | |
| ≥80 | 445 (36.4) | 7516 (41.3) | |
| Sex | <0.001 | ||
| Female | 543 (44.4) | 9143 (50.3) | |
| Male | 680 (55.6) | 9039 (49.7) | |
| Race | <0.001 | ||
| White | 1026 (83.9) | 16001 (88.0) | |
| Black | 146 (11.9) | 1572 (8.6) | |
| Othersb | 48 (3.9) | 594 (3.3) | |
| Unknown | 3 (0.2) | 15 (0.8) | |
| Marital status | 0.555 | ||
| Married | 637 (52.1) | 9202 (50.6) | |
| Not marriedc | 545 (44.6) | 8393 (46.2) | |
| Unknown | 41 (3.4) | 587 (3.2) | |
| Laterality | 0.019 | ||
| Left | 499 (40.8) | 7380 (40.6) | |
| Right | 684 (55.9) | 9981 (54.9) | |
| Bilateral | 16 (1.3) | 176 (1.0) | |
| Unknown | 24 (2.0) | 645 (3.5) | |
| SEER stage | <0.001 | ||
| Localized | 316 (25.8) | 1126 (6.2) | |
| Regional | 390 (31.9) | 4368 (24.0) | |
| Distant | 504 (41.2) | 12267 (67.5) | |
| Unknown | 13 (1.1) | 421 (2.3) | |
| Tumor size (cm) | <0.001 | ||
| ≤3 | 465 (38.0) | 3329 (18.3) | |
| 3-5 | 277 (22.6) | 3243 (17.8) | |
| 5-7 | 147 (12.0) | 2195 (12.1) | |
| >7 | 142 (11.6) | 2463 (13.5) | |
| Unknown | 192 (15.7) | 6952 (38.2) | |
| Nodal status | <0.001 | ||
| No | 563 (46.0) | 2997 (16.5) | |
| Yes | 595 (48.7) | 12922 (71.1) | |
| Unknown | 65 (5.3) | 2263 (12.4) | |
| Surgery | <0.001 | ||
| No | 620 (50.7) | 17374 (95.6) | |
| Yes | 599 (49.0) | 649 (3.6) | |
| Unknown | 4 (0.3) | 159 (0.9) | |
| Radiation | <0.001 | ||
| No/ Unknown | 801 (65.5) | 9776 (53.8) | |
| Yes | 422 (34.5) | 8406 (46.2) | |
| Chemotherapy | <0.001 | ||
| No/ Unknown | 595 (48.7) | 5674 (31.2) | |
| Yes | 628 (51.3) | 12508 (68.8) |
Abbreviations: LCNEC, large cell neuroendocrine carcinoma; SCLC, small cell lung carcinoma; SEER, Surveillance Epidemiology and End Results database.
a P value between high-grade LCNEC and SCLC was calculated by chi-square test.
b Others included American Indian/Alaskan native, and Asian/Pacific islander.
c Not married included separated, single (never married), divorced, unmarried or domestic partner and widowed.