Table 3.
Subgroup analysis of high-grade LCNEC and SCLC with SEER stage and surgery.
| Overall survival | Cancer-special survival | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| SEER stage | ||||||||
| Localized | ||||||||
| LCNEC | Reference | — | Reference | — | Reference | — | Reference | — |
| SCLC | 2.14 (1.81-2.53) | <0.001 | 1.19 (0.96-1.48) | 0.120 | 2.36 (1.95-2.86) | <0.001 | 1.17 (0.91-1.51) | 0.226 |
| Regional | ||||||||
| LCNEC | Reference | — | Reference | — | Reference | — | Reference | — |
| SCLC | 1.16 (1.06-1.28) | <0.001 | 1.33 (1.15-1.54) | <0.001 | 1.17 (1.06-1.29) | <0.001 | 1.37 (1.17-1.60) | <0.001 |
| Distant | ||||||||
| LCNEC | Reference | — | Reference | — | Reference | — | Reference | — |
| SCLC | 1.16 (1.06-1.28) | 0.002 | 1.14 (1.03-1.25) | 0.009 | 1.17 (1.06-1.29) | 0.001 | 1.13 (1.03-1.25) | 0.013 |
| Surgery | ||||||||
| No | ||||||||
| LCNEC | Reference | — | Not applicable | Reference | — | Not applicable | ||
| SCLC | 1.06 (0.98-1.16) | 0.155 | Not applicable | 1.06 (0.97-1.16) | 0.216 | Not applicable | ||
| Yes | ||||||||
| LCNEC | Reference | — | Reference | — | Reference | — | Reference | — |
| SCLC | 1.39 (1.21-1.59) | <0.001 | 1.31 (1.12-1.53) | 0.001 | 1.55 (1.33-1.81) | <0.001 | 1.39 (1.17-1.65) | <0.001 |
Abbreviations: LCNEC, large cell neuroendocrine carcinoma; SCLC, small cell lung carcinoma; SEER, Surveillance Epidemiology and End Results database; HR, hazard ratio; CI, confidence interval.