Table 4.
Clinicopathological characteristics of high-grade LCNEC and SCLC patients without surgery in 1:1 matched group
| Before the match | After the match | |||||
|---|---|---|---|---|---|---|
| LCNEC N=620 (%) |
SCLC N=17374 (%) |
P valuea | LCNEC N=620 (%) |
SCLC N=620 (%) |
P value | |
| Age | 0.431 | 0.16 | ||||
| <60 | 160 (25.8) | 4340 (25.0) | 160 (25.8) | 163 (26.3) | ||
| 60-79 | 219 (35.3) | 5835 (33.6) | 219 (35.3) | 189 (30.5) | ||
| ≥80 | 241 (38.9) | 7199 (41.4) | 241 (38.9) | 268 (43.2) | ||
| Sex | <0.001 | 0.954 | ||||
| Female | 254 (41.0) | 8718 (50.2) | 254 (41.0) | 253 (40.8) | ||
| Male | 366 (59.0) | 8656 (49.8) | 366 (59.0) | 367 (59.2) | ||
| Race | 0.001 | 0.705 | ||||
| White | 512 (82.6) | 15266 (87.9) | 512 (82.6) | 517 (83.4) | ||
| Black | 79 (12.7) | 1513 (8.7) | 79 (12.7) | 78 (12.6) | ||
| Othersb | 27 (4.4) | 580 (3.3) | 27 (4.4) | 25 (4.0) | ||
| Unknown | 2 (0.3) | 15 (0.1) | 2 (0.3) | 0 (0.0) | ||
| Marital status | 0.562 | 0.072 | ||||
| Married | 301 (48.5) | 8744 (50.3) | 301 (48.5) | 341 (55.0) | ||
| Not marriedc | 296 (47.7) | 8072 (46.5) | 296 (47.7) | 257 (41.5) | ||
| Unknown | 23 (3.7) | 558 (3.2) | 23 (3.7) | 22 (3.5) | ||
| Laterality | 0.004 | 0.964 | ||||
| Left | 231 (37.3) | 7012 (40.4) | 231 (37.3) | 232 (37.4) | ||
| Right | 350 (56.5) | 9560 (55.0) | 350 (56.5) | 352 (56.8) | ||
| Bilateral | 16 (2.6) | 170 (1.0) | 16 (2.6) | 13 (2.1) | ||
| Unknown | 23 (3.7) | 632 (3.6) | 23 (3.7) | 23 (3.7) | ||
| SEER stage | 0.426 | 0.28 | ||||
| Localized | 38 (6.1) | 909 (5.2) | 38 (6.1) | 54 (8.7) | ||
| Regional | 130 (21.0) | 4011 (23.1) | 130 (21.0) | 139 (22.4) | ||
| Distant | 441 (71.1) | 12069 (69.5) | 441 (71.1) | 416 (67.1) | ||
| Unknown | 11 (1.8) | 385 (2.2) | 11 (1.8) | 11 (1.8) | ||
| Tumor size (cm) | <0.001 | 1.000 | ||||
| ≤3 | 136 (21.9) | 2931 (16.9) | 136 (21.9) | 138 (22.3) | ||
| 3-5 | 115 (18.5) | 3094 (17.8) | 115 (18.5) | 114 (18.4) | ||
| 5-7 | 91 (14.7) | 2140 (12.3) | 91 (14.7) | 91 (14.7) | ||
| >7 | 104 (16.8) | 2407 (13.9) | 104 (16.8) | 102 (16.5) | ||
| Unknown | 174 (28.1) | 6802 (39.2) | 174 (28.1) | 175 (28.2) | ||
| Nodal status | <0.001 | 0.954 | ||||
| No | 146 (23.5) | 2668 (15.4) | 146 (23.5) | 150 (24.2) | ||
| Yes | 419 (67.6) | 12531 (72.1) | 419 (67.6) | 417 (67.3) | ||
| Unknown | 55 (8.9) | 2175 (12.5) | 55 (8.9) | 53 (8.5) | ||
| Radiation | 0.176 | 0.078 | ||||
| No/ Unknown | 314 (50.6) | 9285 (53.4) | 314 (50.6) | 346 (55.8) | ||
| Yes | 306 (49.4) | 8089 (46.6) | 306 (49.4) | 274 (44.2) | ||
| Chemotherapy | <0.001 | 0.953 | ||||
| No/ Unknown | 234 (37.7) | 5380 (31.0) | 234 (37.7) | 232 (37.4) | ||
| Yes | 386 (62.3) | 11994 (69.0) | 386 (62.3) | 388 (62.6) | ||
Abbreviations: LCNEC, large cell neuroendocrine carcinoma; SCLC, small cell lung carcinoma; SEER, Surveillance Epidemiology and End Results database.
a P value between high-grade LCNEC and SCLC was calculated by chi-square test.
b Others included American Indian/Alaskan native, and Asian/Pacific islander.
c Not married included separated, single (never married), divorced, unmarried or domestic partner and widowed.