Table 4.
Performance of the ddPCR assay for detecting cfDNA EGFR mutations in comparison with NGS.
cfDNA ddPCR | NGS | Concordance | Kappa | P | ||
---|---|---|---|---|---|---|
Positive | Negative | (%) | ||||
E746_A750del | Positive | 16 | 3 | 89.5 | ||
Negative | 3 | 35 | 0.763 | <0.001 | ||
L858R | Positive | 14 | 1 | 98.3 | ||
Negative | 0 | 42 | 0.954 | <0.001 | ||
T790M | Positive | 6 | 2 | |||
Negative | 2 | 47 | 93.0 | 0.709 | <0.001 |