Table 3.
HTSH295RAC50 (μM) values for 17α-hydroxyprogesterone and 11-deoxycorticosterone showing that responders in the 96-well format of the Leydig cell assay have AC50 values <3 μM.
| Responders | AC50 (μM) |
Non responders | AC50 (μM) |
|---|---|---|---|
| Category 1: AC50 for 17α-hydroxyprogesterone in the HTS H295R assay | |||
| Metconazole | 0.09 | Permethrin | 9.99 |
| Cycloheximide | 0.10 | Esfenvalerate | 27.50 |
| Tamoxifen citrate | 0.14 | ||
| 17α-Ethynylestradiol | 0.33 | ||
| 3,4,4|-Trichlorocarbanilide | 0.37 | ||
| Flusilazole | 0.38 | ||
| Simvastatin | 0.72 | ||
| Flufenoxuron | 1.09 | ||
| Finasteride | 1.13 | ||
| Triphenyl phosphate | 1.81 | ||
| Spirodiclofen | 2.01 | ||
| Corticosterone | 44.16 | ||
| Category 2: AC50 for 11-deoxycorticosterone in the HTS H295R assay | |||
| 1,4-Dihydroxy-2-naphthoic acid | 0.43 | Prednisone | 39.51 |
| Dimethipin | 1.59 | ||
| 4-Chloro-1,2-diaminobenzene | 2.69 | ||
| Anilazine | 2.84 | ||
| Hydroquinone | 3.20 | ||
Corticosterone does not follow <3 μM pattern.