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. Author manuscript; available in PMC: 2019 Aug 13.
Published in final edited form as: J Neurol Sci. 2015 Jun 27;357(1-2):28–34. doi: 10.1016/j.jns.2015.06.055

Figure 4.1 –

Figure 4.1 –

The final infarct volume was identified by serial DWI images and T2WI on different time points.

The infarct volumes of vehicle group (blue line) were significantly larger than those in NRG-1 treated group at all time points post occlusion (all p<0.05). When comparison of the stroke volume in mild (red line, square marker) and severe ischemia group (green line, triangle marker) according to CBF reduction during surgery, the neuroprotective effects of NRG-1 seems more obvious in the mild ischemia group. At 2 and 3 hr post occlusion, there were 47% and 53% volume reduction in mild ischemic group compared to those in severe goup (p<0.05). On 48 hr post occlusion, 47% volume reduction is noticed in the mild group compared to severe group (180.8 ± 70.8 vs. 321.0 ± 232.3 mm3, p<0.05). The star indicated the significant difference between vehicle and severe ischemia group.