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. 2019 Jun 19;9:10.7916/d8-28jq-8t52. doi: 10.7916/d8-28jq-8t52

Table 3.

Studies on the effect of intervention on Balance and Gait in Essential Tremor

First Author, Year ET (n) Control (n) Age (Years) Intervention Assessment Outcomes Results
Ondo et al.53 13 ET 72.8 Thalamic stimulation QP (sensory organization test) 1. Time to onset of compensatory movements;
2. Amplitude of compensatory movements
Performance on the sensory organization test was worse with DBS off and improved with DBS;
Fasano et al.51 11 ET
10 control
69.8;
67.3
Bilateral thalamic stimulation NE;
QG (standard and tandem walk on treadmill)
1.Tremor rating scale;
2. Intention tremor score; 3. Spiral score;
4. Postural tremor score; 5. Overground tandem gait velocity;
6. Overground tandem number missteps;
7. Ataxia score;
8. Swing duration CV;
9. Range of motion
1. Total tremor score, intention tremor, postural tremor, and spiral tremor, was reduced with thalamic stimulation; 2. Supra therapeutic stimulation improved tremor except during upper limb spirals; 3. Number of missteps was reduced on thalamic stimulation, but was higher than healthy controls; 3. Supratherapeutic stimulation increased number of missteps; 4. With assisted tandem gait on treadmill lower limb kinematics were highly variable; 5. Thalamic stimulation improved ataxia ratio and variability
Fasano et al.52 11 ET
10 control
69.8;
67.3
Bilateral thalamic stimulation NE;
QG (standard and tandem walk on treadmill)
1. ICARS score;
2. Gait speed;
3. Stride length;
4. Swing duration;
5. Double support time;
6. Step width;
7. Step height;
8. Ataxia score;
9. Swing duration CV;
10. Range of motion
1. Thalamic stimulation reduced intention and postural tremor; 2. Joint ROM in ET patients with normal kinematics was similar to controls; 3. ET patients with impaired kinematics (longer disease duration and greater intention tremor) had higher variability in joint movement; 4. Thalamic stimulation reduced joint variability in ET with impaired kinematics
Hwynn et al.56 38 ET 67.1 Thalamic stimulation (unilateral and bilateral) NE;
QG and falls assessment
1. Fahn–Tolosa–Marin tremor rating scale;
2. Upper extremity scores (rest tremor, postural tremor, kinetic tremor, drawing spirals, pouring water into cup);
3. Gait and falls assessment
1. About 70% of patients with unilateral thalamic stimulation and 55% with bilateral thalamic stimulation reported worsened gait; 2. Patients with worsened gait had poor baseline tremor scores
Earhart et al.24 13 ET;
13 control
61.6;
63.2
Bilateral thalamic stimulation NE;
QG (preferred and tandem walk)
1. ABC Scale; 2. Spatiotemporal gait measured with GAITRite mat;
3. BBS;
4. TUG
1. ET patients demonstrated tremor reduction with stimulation; 2. During standard and tandem walk, ET patients walked with slower speed, lower cadence, and higher double support during ON and OFF stimulation compared with controls; 3. ET patients performed worse on clinical tests of balance compared with controls; 4. There were no differences with DBS on and off
Ulanowski et al.47 1 ET 61 Physical therapy (balance and functional movement training) for 14 sessions over 8 weeks Standardized clinical assessment 1. BBS;
2. FGA,
3. Five-times-sit-to-stand test
4.10-m walk test (10MWT).
After 8 weeks of therapy, the patient had clinically meaningful changes in the five-times-sit-to-stand test, FGA, and BBS. The improvement reduced fall risk

Abbreviations: ABC, Activities of Balance Confidence; BBS, Berg Balance Scale; CV, Coefficient of Variation; ET, Essential Tremor; FGA, Functional Gait Assessment; ICARS, International Cooperative Ataxia Rating Scale; NE, Neurological Examination; QG, Quantitative Gait; QP, Quantitative Posturography; TUG, Timed Up and Go.