Table 3.
Enzymatic activities of compound 23b.
| IC50 | 23b (μM) | Selectivity (fold) |
|---|---|---|
| BRAFWT | >20 | – |
| BRAFV600E | 0.10 (>200 fold) | >200 |
| CRAF | 0.02 (1000 fold) | >1000 |
| A37521 | 0.07 μM (GI50) | |
| SW62021 | >10 μM (GI50) | |
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