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Inhibitory evaluation of compound 5 against EGFR, VEGFR-2, CDK-2 and c-Kit kinases.
| Kinase | IC50 (mean ± SD) (µM) |
|
|---|---|---|
| 5 | Staurosporine | |
| EGFR | 0.78 ± 1.25 | 1.00 ± 1.12 |
| VEGFR-2 | 3.17 ± 1.00 | 0.08 ± 1.10 |
| CDK-2 | 6.24 ± 1.21 | 0.11 ± 1.13 |
| c-kit | 2.85 ± 0.04 | 0.60 ± 1.00 |
IC50: compound concentration required to inhibit the enzyme activity by 50%, SEM = standard error mean; each value is the mean of three values.
