Table 1.

The VEGFR-2 inhibition per cent of the synthesised phthalazines (series A, B, C) at 10 μM concentration.

Cpd No	X	R	R1	R2	% inhibition
5a	–	H	H	–	4
5b	–	H	Cl	–	8
5c	–	CH3	H	–	12
5d	–	CH3	Cl	–	15
6a	NH	H	H	H	13
6b	NH	H	Cl	H	20
6c	NH	H	Cl	CF3	70
6d	NH	CH3	H	H	15
6e	NH	CH3	Cl	H	19
6f	NH	CH3	Cl	CF3	32
12a	NH	Cl	H	H	26
12b	NH	Cl	Cl	H	70
12c	NH	Cl	Cl	CF3	78
7a	O	H	H	H	5
7b	O	H	Cl	H	13
7c	O	H	Cl	CF3	47
7d	O	CH3	H	H	10
7e	O	CH3	Cl	H	14
7f	O	CH3	Cl	CF3	21
13a	O	Cl	H	H	24
13b	O	Cl	Cl	H	38
13c	O	Cl	Cl	CF3	100
Staurosporin					100

The bold values are the most active compounds.