Table 2.

The VEGFR-2 inhibition per cent of the synthesised phthalazines (series D, E, F) at 10 μM concentration.

Cpd No	Y	X	R	R1	% inhibition
16a	NH	H	–	–	47
16b	NH	Cl	–	–	21
16c	NH	CH3	–	–	19
16d	NH	OCH3	–	–	24
17a	O	H	–	–	31
17b	O	CH3	–	–	15
8a	–	–	H	ethoxycarbonyl	13
8b	–	–	H	phenyl	8
8c	–	–	H	2-fluorophenyl	9
8d	–	–	H	pyridyl	5
8e	–	–	H	2-furoyl	9
8f	–	–	CH3	ethoxycarbonyl	14
8g	–	–	CH3	phenyl	13
8h	–	–	CH3	2-fluorophenyl	9
8i	–	–	CH3	pyridyl	6
8j	–	–	CH3	2-furoyl	10
Staurosporin	–	–	–	–	100

The bold values are the most active compounds.