Table 1.
Demographic, clinical and MRI parameters of the cohort.
| All patients | Mild disability EDSS 0–3.0 | Moderate disability EDSS ≥ 3.5 | |
|---|---|---|---|
| n patients (% women) | 1,249 (71) | 902 (70) | 347 (75.5) |
| Mean age years ± SD | 40.6 ± 9.7 | 38.8 ± 9.0 | 45.5 ± 7.9 |
| Mean DD years ± SD | 11.1 ± 7.7 | 9.36 ± 6.8 | 15.59 ± 7.93 |
| Median EDSS (min.–max.) | 2.5 (0–7.0) | 2.0 (0–3) | 4.0 (3.5–7) |
| MUCCA (mm2 ± SD) | 83.95 ± 9.69 | 85.99 ± 8.81 | 78.65 ± 9.86 |
| Spinal cord phenotype | |||
| Normally appearing n (%) | 424 (33.9) | 346 (38.4) | 78 (22.5) |
| Focal lesions n (%) | 318 (25.5) | 225 (24.9) | 93 (26.8) |
| Diffuse changes n (%) | 326 (26.1) | 217 (24.1) | 109 (31.4) |
| Diffuse changes and focal lesions n (%) | 181 (14.5) | 114 (12.6) | 67 (19.3) |
DD, disease duration; EDSS, Expanded Disability Status Scale; MUCCA, mean upper cervical cord area; SD, standard deviation.