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. 2019 Aug 6;9:692. doi: 10.3389/fonc.2019.00692

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Copyright © 2019 Saha, Murmu, Biswas, Chakraborty, Basu, Madhulika, Kolapalli, Chauhan, Sengupta and Prasad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of RNA binding proteins (RBPs). Flowchart showing hematopoietic hierarchy during normal differentiation and leukemia, followed by the systematic work plan adapted in this study to understand the potential role of RBPs in normal and malignant hematopoiesis (A). Pie graph showing the classification of 1,734 RBPs based on their function and RNA counterparts, such as mRNA binding (mRBP), ribosome (rRBP), tRNA binding (tRBP), rRNA binding (rrRBP), ncRNA binding (ncRBP), snRNA binding (snRBP), and “diverse” targets, and RBPs with “unknown” interacting partner (B). Stacked bar plots showing genetic alteration frequency of RBP functional classes in AML TCGA dataset comprising of 162 patients (C). Bar plot showing distribution of 82 RBPs across different cancers identified from Cosmic database; TSG (tumor suppressor gene) (D). Stacked bar plot depicting RBP subclasses reported in LGL database (E). Venn diagram showing overlap between RBP genes identified from COSMIC database and LGL database (F).