Table 3.
KEGG enrichment items pathways and regulatory genes of three significant SNPs.
| KEGG ID | KEGG term | False discovery rate (FDR) | Enrichment score | Differentially expressed gene (DEG) |
|---|---|---|---|---|
| Path:ko04064 | NF-kappa B signaling pathway* | 2.16E-4 | 1.398 | CARD11; CHUK; RELB; MAP3K7; CARD14; TAB1; ATM; SYK; IL1B; CSNK2A1; LBP; TRIM25; PLCG2; IKBKB; CD40; TNFRSF11A; TIRAP; CARD10; DDX58; PRKCB |
| Path:ko04662 | B cell receptor signaling pathway* | 2.53E-4 | 1.378 | CARD11; DAPP1; CHUK; PIK3CB; GSK3B; PPP3CA; SYK; VAV3; NFATC2; PTPN6; INPP5D; PLCG2; IKBKB; PIK3R2; AKT2; PRKCB |
| Path:ko04151 | PI3K-Akt signaling pathway* | 5.15E-4 | 1.311 | ITGA8; TNR; THBS1; CDK6; GNB5; PRKAA2; CHUK; ITGB8; GH1; IL2RA; PCK1; FGF13; PDGFA; FGF14; EIF4B; PTK2; CREB1; CDKN1B; PIK3CB; PRKCA; PIK3R5; VEGFC; FN1; PKN1; IL7R; GYS1; EGF; GSK3B; RELN; LAMA4; EFNA3; SYK; LAMB1; FGFR2; ANGPT4; ITGA9; COL4A6; IGF1R; IBSP; MYB; FGF12; CREB5; COL4A2; PGF; COL6A3; RBL2; PHLPP2; RPTOR; IL3RA; LAMA3; LOC104968606; IKBKB; LAMA2; PIK3R2; FLT3; PDPK1; COL9A2; PHLPP1; IFNAR2; AKT2; MET; TNXB; PRLR; ITGA2; LAMC2; PPP2R2B; BCL2L11; PDGFD; THBS4; LPAR1; CSF3R; PPP2CB; LAMA1; LOC530102 |
| Path:ko04650 | Natural killer cell mediated cytotoxicity*, ** | 8.26E-4 | 1.953 | LCP2; LOC100850276; SHC3; PTK2B; PIK3CB; PRKCA; CD247; SH2D1B; PPP3CA; SYK; VAV3; NFATC2; PTPN6; PLCG2; PIK3R2; ITGAL; IFNAR2; BRAF; PRKCB |
| Path:ko04660 | T cell receptor signaling pathway | 3.02E-3 | 1.279 | CARD11; LCP2; CHUK; MAP3K7; PAK6; PIK3CB; NCK2; CD247; PAK7; GSK3B; PPP3CA; VAV3; NFATC2; PTPN6; IKBKB; PIK3R2; PDPK1; IL5; CD28; AKT2; TEC |
| Path:ko04062 | Chemokine signaling pathway** | 7.12E-3 | 1.227 | DOCK2; TIAM1; GNB5; SHC3; CHUK; PTK2B; PTK2; ADCY2; PIK3CB; LOC508666; GRK5; CCL5; CCR8; GSK3B; ADCY5; VAV3; STAT5B; PREX1; STAT3; ADCY1; IKBKB; PIK3R2; ELMO1; AKT2; PLCB1; CCR9; BRAF; PARD3; PRKCB |
| Path:ko04060 | Cytokine-cytokine receptor interaction*** | 9.15E-3 | 1.119 | IL12RB2; IL18; GH1; IL2RA; PDGFA; IFNE; IL1RAP; LOC508666; IL20RA; IL12RB1; VEGFC; TNFSF18; RELT; IL7R; CCL5; IFNL3; CCR8; EGF; IL17C; IL1B; IL1R2; IL18R1; IL3RA; FLT3; CD40; TNFRSF11A; TNFRSF21; BMPR1A; IL5; IFNAR2; IL17B; CCR9; MET; PRLR; IL10RA; ACVR1; PDGFD; IL13RA1; CSF3R |
*
SYK gene is involved in KEGG enrichment pathway.
**
PTK2B gene is involved in KEGG enrichment pathway.
***
TNFRSF21 gene is involved in KEGG enrichment pathway.