Table 3.
Hematological and biochemical data in diabetic and nondiabetic dialysis patients.
| Non diabetic patients (n = 148) | Diabetic patients (n = 98) | P | |
|---|---|---|---|
| Hematological data | |||
| Erythrocytes (× 1012/L) | 3.70 (3.40 –3.96) | 3.84 (3.54–4.09) | .007 |
| Hemoglobin (g/dL) | 11.4 (10.6–12.1) | 11.5 (10.9–12.2) | .301 |
| Hematocrit (%) | 34.8 (32.5–37.2) | 35.5 (33.9–37.2) | .103 |
| Reticulocytes (×109/L) | 38.5 (26.1–54.2) | 45.9 (27.2–67.8) | .042* |
| RPI | 0.61 (0.46–0.90) | 0.78 (0.50–1.23) | .010 |
| MCV (fL) | 95.3 ± 5.4 | 93.3 ± 5.4 | .004 |
| MCH (pg) | 31.2 (30.1–32.1) | 30.5 (29.3–31.4) | .002 |
| MCHC (g/dL) | 32.5 (31.9–33.2) | 32.4 (31.7–33.1) | .770 |
| Platelets (×109/L) | 194 (152–232) | 200 (165–232) | .307 |
| Leukocytes (×109/L) | 5.8 (5.0–7.2) | 6.7 (5.6–8.0) | <.001 |
| Iron metabolism markers | |||
| Iron (µg/dL) | 54.0 (45.0–75.0) | 60.0 (46.0–73.0) | .631 |
| Transferrin (mg/dL) | 184.0 (163.2–213.0) | 196.0 (165.8–224.0) | .163 |
| Transferrin saturation (%) | 21.2 (15.6–28.0) | 22.7 (16.2–27.0) | .963 |
| sTfR (nM) | 19.8 (15.8–27.6) | 24.7 (19.6–29.4) | .002 |
| Ferritin (ng/mL) | 328.0 (177.2–469.8) | 285.0 (173.8–448.5) | .247 |
| Hepcidin (ng/mL) | 78.6 (43.2–139.0) | 73.0 (34.1–126.4) | .246 |
| Inflammatory markers | |||
| IL-6 (pg/mL) | 4.07 (2.62–7.82) | 4.10 (2.63–6.88) | .802 |
| hs-CRP (mg/dL) | 0.42 (0.19–0.87) | 0.28 (0.12–0.65) | .023 |
| TNF-α (pg/mL) | 3.40 (2.70–4.59) | 3.27 (2.44–3.94) | .089 |
| GDF15 (pg/mL) | 11,300 (8400–14,170) | 12,120 (9040–14,610) | .186 |
Values are presented as mean ± SD or median (interquartile range).
RPI: reticulocyte production index; MCV: mean cell volume; MCH: mean cell hemoglobin; MCHC: mean cell hemoglobin concentration; sTfR: soluble transferrin receptor; IL-6: interleukin-6; hs-CRP: high sensitivity C-reactive protein; TNF: tumor necrosis factor; GDF15: growth differentiation factor 15.
*Significance was lost (p = .083) after adjustment for BMI.