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. Author manuscript; available in PMC: 2019 Nov 21.
Published in final edited form as: Bioconjug Chem. 2018 Oct 16;29(11):3626–3637. doi: 10.1021/acs.bioconjchem.8b00564

Figure 6.

Figure 6.

Highly selective in vivo endothelial targeting of 111In labeled anti CAM mAb and scFv click radioimmunoliposome. Biodistribution of 111In labeled anti PECAM liposomes injected in Naïve mice 30 min after administration by injected dose per gram of tissue. (a) Mouse PECAM (clone 390) click radioimmunoliposome of mAb (blue) and scFv (green) accumulation by organ versus untargeted immune controls IgG (red) and untargeted scFv (teal). (b) Immunospecificity index, the ratio of signal localized in organs normalized to blood signal of targeted to control click radioimmunoliposome, of data in (a). (c) Biodistribution of ICAM (clone YN1) targeting of mAb and scFv as in (a) and (d) immunospecificity as in (b). Error bars represent standard deviation, n ≥ 3–4.