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. 2019 Jun 17;47(2):207–216. doi: 10.1080/12298093.2019.1620975

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the Korean Society of Mycology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Knockout of AcuD attenuated virulence of T. marneffei. (A) The survival rates of zebrafish larvae inoculated with different T. marneffei strains and co-incubated at 28 °C (n = 100); (B) T. marneffei CFU time-course counts of different groups, mean ± SD, n = 5 larvae/group/experiment. Different colors indicate six independent experiments. WT1 × 10⁸, SPM4, ΔAcuD, ΔAcuD+ stands for inoculated at an amount of 1 × 10⁸ CFU/ml yeast cells of wild-type strain SUMS0594, SPM4, AcuD knockout mutant, AcuD complement mutant respectively; Heat inactive: heat-inactivated yeast cells of SUMS0594 at an amount of 1 × 10⁸ CFU/ml; PBS: sterile phosphate-buffered saline. ****indicates a p value < .0001. (C) A large number of granular bulges can be seen at the injection site of the zebrafish at 24 hpi (left), few mycelia grow out through the granular bulge at 48 hpi. Zebrafish larvae from the ΔAcuD group.