Table 1.

Virulence phenotypes of AcuD gene mutant during interactions with host organisms.

Fungal pathogen	Mutant	Host model	Virulence	Reference
Human-related pathogenic fungi
Candida glabrata	ΔAcuD	Murine	Less virulent	[9]
Talaromyces marneffei	AcuDacuD-RNAi AcuDacuD-RNAqb	Murine	Less virulent	[10]
Aspergillus fumigatus	ΔAcuD	Murine	Virulent	[11]
Cryptococcus neoformans	ΔAcuD	Rabbit Murine	Virulent	[12]
Candida albicans	ΔAcuDa	Murine	Less virulent	[13]
Plant-related pathogenic fungi
Colletotrichum lagenarium	ΔAcuD	Cucumber	Less virulent	[14]
Magnaporthe grisea	ΔAcuD	Rice	Less virulent	[15]
Leptosphaeria maculans	ΔAcuD	Cotyledons	Less virulent	[16]

ΔAcuD stand for AcuD knockout mutant.

^aVarious names have been used in the literature for the gene encoding ICL in different organisms; for clarity, the designation AcuD is used here.

^bAcuD gene was knocked down by RNAi-mediated silencing.