Table 1.

Highlights of studies on pain treatment in chronic pancreatitis

Study	Design	N	Interventions	Follow-up	Pain relief (%)*
Endoscopy
Rosch et al 12	Cohort	1018	Endoscopy (including ESWL)	4.9 years†	65
Tadenuma et al 71	Cohort	57	Endoscopy (including ESWL)	1 year	63
Dumonceau et al 72	RCT	55	ESWL with/without subsequent endoscopy	2 years	55 vs 62 (p=0.651)
Conventional surgery
Dite et al 61	RCT	72	Endoscopy (without ESWL) versus surgery	5 years	61 vs 86 (p=0.002)
Cahen et al 13	RCT	39	Endoscopy (including ESWL) versus surgery	2 years	32 vs 75 (p=0.007)
Cahen et al26	Long-term results RCT	31	Endoscopy (including ESWL) versus surgery	>6 years	38 vs 80 (p=0.042)
TPIAT
Bellin et al 82	Cohort	215	TPIAT	10 years	82
Neuropathic pain medication
Olesen et al67	RCT	64	Pregabalin versus placebo	3 weeks	36 vs 24 (p=0.02)

*Complete and partial pain relief combined.

†Mean.

CP, chronic pancreatitis; ESWL, extracorporeal shockwave lithotripsy; RCT,  randomised controlled trial; TPIAT, total pancreatectomy with islet autotransplantation.