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. 2019 Aug 2;13:769. doi: 10.3389/fnins.2019.00769

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Copyright © 2019 Feng, Chen, Sung, Kuo, Yang, Chen, Hung, Chen, Wen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The treatment of TREM-1 agonist antibody reduced the anti-inflammatory effects of LP17 on iNOS and COX-2 expressions in LPS-stimulated murine BV-2 microglial cell line (n = 4/group). Western blotting for iNOS and COX-2 expression of control, LPS, LPS plus LP17, LPS plus LP17 + agonist antibody, and agonist antibody group after the BV-2 microglial cells were treated with 10 μg/ml LP17 plus 100 ng/ml LPS for 6 h and 30 min, followed by the addition of 5 μg/ml TREM-1 agonist antibody to the solution for 16 h. The agonist antibody significantly inhibited the anti-inflammatory effect of LP17 on LPS-induced upregulation of iNOS and COX-2 expressions. The bars represent the mean ± SEM. The data were analyzed using two-way ANOVA.^∗∗P < 0.05 versus the control group; ^##P < 0.05 versus the LPS group.