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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: J Mol Endocrinol. 2019 Aug 1;63(2):123–138. doi: 10.1530/JME-19-0021

Figure 2. Fibroblasts from GHR−/− and DW mice show upregulation of protein degradation compared to control mice.

Figure 2.

A) Representative western blots comparing degradation of MGMT, NDRG1, TFAM, LONP1, YTHDF1 and PGC1 proteins between control and GHR−/− fibroblasts at different time points during cycloheximide treatments. Extracts were normalized to actin. B) Bar graphs represent the mean ± S.E.M. of the half-life for each protein relative to actin from fibroblasts of 4 GHR−/− mice per group (2 females) and 5 DW mice per group (2 females). Each symbol represents a different mouse, and (*) indicates statistical significance (p<0.05) relative to controls.