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The functions of HOXA11 and HOXA11-AS in cisplatin (DDP) resistance in vitro. HOXA11- and HOXA11-AS-specific siRNAs were transfected or cotransfected into A549 cells, and HOXA11 and HOXA11-AS overexpression vectors were transfected or cotransfected into A549/DDP cells. Using a CCK-8 assay, cell proliferation was analyzed (a), and the IC50 values of DDP were calculated (b). Flow cytometry and TUNEL assays revealed the cell cycle and apoptosis in A549 (c) and A549/DDP cells (d).
