Skip to main content
. 2019 May 30;14(9):850–876. doi: 10.1080/15592294.2019.1615357

Figure 3.

Figure 3.

An example of differentially expressed miRNAs (DE-miRNAs) detected in bovine muscle with close proximity (<50 kb) on chromosome 21. In muscle of LOS foetuses, eight DE-miRNAs were found from this ~610-kb region and six of them belong to the DLK1-DIO3 genomic imprinted cluster. Two hypermethylated differentially methylated regions (DMRs) were detected at ~230-kb and ~279-kb upstream regions of DLK1-DIO3 cluster. Triangles/circles/rhombuses = locations of miRNAs on the chromosome (not drawn to scale). Filled lollipops = hypermethylated DMRs. Solid lines = chromosome 21. Dashed lines = start and end positions of this chromosome region with million bases (Mb) as unit. ‘+’ = sense strand of chromosome 21. ‘-’ = antisense strand of chromosome 21. Low expression miRNAs = miRNAs that were not detected or failed to pass the low expression cut-off in muscle. Non-DE-miRNAs = miRNAs that passed the low expression cut-off but were not detected as DE-miRNAs by any methods and grouping strategies in muscle. DE-miRNAs = miRNAs detected as DE-miRNAs in muscle by any of the methods and grouping strategies. For entire lists of genome locations of DE-miRNAs in muscle, kidney, liver, and tongue please refer to Supplementary Table S6A, S6B, S6C, and S6D, respectively.