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. 2019 May 30;14(9):850–876. doi: 10.1080/15592294.2019.1615357

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 4. — An example of differentially expressed miRNAs (DE-miRNAs) associated with differentially methylated regions (DMRs) within 10-kb upstream regions of their transcription start sites (TSS). A hypomethylated DMR was found within 10-kb upstream regions of predicted TSS regions of upregulated bta-miR-132 in LOS muscle. The TSS regions were predicted based on two human databases, namely mirTrans and miRStart. Line arrows = chromosome 19 antisense strand. Dashed elbow arrows = predicted TSS and miRNA expression. Solid elbow arrows = predicted TSS and upregulated miRNA expression. Solid filled black rectangles = pre-miRNAs. Striped rectangles = predicted TSS regions. Grey rectangles = DMRs. Open lollipops = unmethylated CpG sites. Filled lollipops = methylated CpG sites. For all the association between DE-miRNAs and DMRs refer to Table 3.