Table 3. DANA and biomarker concentrations before and after overpressure exposure.
DANA (milliseconds) | Pre-Exp | Post-Exp | % Change | p-value | ||
Median | IQR | Median | IQR | |||
SRT | 269.0 | 256.6–305.7 | 299.9 | 273.5–330.6 | 11.5 | 0.048* |
PRT | 636.9 | 592.9–672.1 | 633.7 | 601.5–698.7 | -0.50 | 0.398 |
GNG | 604.7 | 554.0–655.7 | 597.6 | 560.1–668.4 | -1.17 | 0.475 |
Serum Biomarker (pg/mL) | Pre-Exp | Post-Exp | % Change | p-value | ||
Median | IQR | Median | IQR | |||
GFAP | 59.2 | 45.3–70.2 | 52.1 | 44.0–70.2 | -12.0 | 0.051 |
UCH-L1 | 7.83 | 2.53–22.1 | 7.07 | 3.00–20.5 | -9.71 | 0.978 |
Nf-L | 4.90 | 3.77–6.71 | 5.23 | 3.73–7.58 | 6.73 | 0.035* |
Tau | 0.07 | 0–0.22 | 0.122 | 0–0.23 | 64.9 | 0.090 |
Aβ-40 | 126 | 92.1–160.0 | 140 | 104.5–164.5 | 11.1 | 0.151 |
Aβ-42 | 5.09 | 2.47–6.55 | 5.19 | 3.80–7.01 | 1.96 | 0.046* |
The quantitative values of DANA neurocognitive tests (simple reaction time, procedural reaction time (PRT), and Go—No Go time, milliseconds) and serum biomarkers (GFAP, UCH-L1, Nf-L, tau, Aβ-40, and Aβ-42 [pg/mL] derived from subjects tested before (pre-) and after (post-) overpressure exposure are indicated. Values are displayed as the median and IQR.