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. 2019 Aug 13;14(8):e0213130. doi: 10.1371/journal.pone.0213130

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© 2019 Ganz et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — (A) 3D-SIM superresolution microscopy images of DEK, EdU and PCNA distribution in early/mid S-phase. U2-OS GFP-DEK cells were treated with EdU for 10 min to label nascent DNA via click chemistry, and PCNA was visualized via indirect immunofluorescence. Shown is a single z-slice from the super-resolved image stack with two magnified insets. Red: GFP-DEK, green: PCNA (green), magenta: EdU. Upper left corner: Pseudo-widefield representation of the same nucleus by superimposition of all z-slices. (B) STORM superresolution microscopy images of DEK and PCNA distribution in early S-phase. DEK (red) and PCNA (green) were visualized via indirect immunofluorescence in U2-OS GFP-DEK cells with Alexa405/Alexa647 photoswitchable dye pairs respectively CF568. Shown is a single z-slice with two magnified insets. Top left corner: Widefield image of the same nucleus.