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. 2019 Aug 13;14(8):e0219351. doi: 10.1371/journal.pone.0219351

Table 3. Factors of preterm labor/ectopic pregnancy stratified by the variables listed in the table by using Cox regression.

Events Preterm labor Ectopic pregnancy
PID With PID Without PID With PID vs. Without PID (Reference) With PID Without PID With PID vs. Without PID (Reference)
Stratified Events Rate Events Rate Adjusted HR 95% CI 95% CI P Events Rate Events Rate Adjusted HR 95% CI 95% CI P
Total 561 1,208.18 1,492 532.46 1.864 1.482 2.062 <0.001 14 30.15 33 11.78 2.121 1.803 3.776. 0.003
Age group (years)
12–19 12 3,215.26 43 2,777.33 0.969 0.878 1.069 0.264 0 0 2 129.18 0.000 - - 0.842
20–29 295 2,801.93 725 1,527.55 1.535 1.391 1.694 <0.001 8 75.98 12 25.28 2.649 1.403 5.007 <0.001
30–39 240 1,543.12 683 788.92 1.637 1.484 1.806 <0.001 5 32.15 14 16.17 1.753 0.928 3.312 <0.001
40–49 14 111.54 41 66.20 1.410 1.278 1.556 <0.001 1 7.97 5 8.07 0.870 0.461 1.644 0.597
50–55 0 0 0 0 - - - - 0 0 0 0 - - - -
Insurance premium (NT$)
<18,000 543 1,200.98 1,458 534.11 1.882 1.705 2.076 <0.001 13 28.75 30 10.99 2.307 1.221 4.359 <0.001
18,000–34,999 15 1,478.78 27 479.19 2.583 2.341 2.849 <0.001 1 98.59 2 35.50 2.449 1.296 4.627 <0.001
≥35,000 3 1,453.28 7 438.85 2.772 2.512 3.058 <0.001 0 0 1 62.69 0.000 - - 0.994
DM
Without 557 1,280.27 1,480 576.41 1.859 1.685 2.051 <0.001 14 32.18 33 12.85 2.207 1.169 4.171 <0.001
With 4 136.65 12 51.18 2.234 2.025 2.465 <0.001 0 - 0 - - - - -
HTN
Without 561 1,288.94 1,491 588.09 1.834 1.662 2.024 <0.001 13 29.87 33 13.02 2.023 1.071 3.823 <0.001
With 0 0 1 3.75 0.000 - - 0.894 1 34.37 0 0.00 - - 0.987
Hyperlipidemia 561 1,227.64 1,492 543.45 1.899 1.721 2.095 <0.001 14 30.64 33 12.02 2.257 1.195 4.265 0.012
Obesity 561 1,209.77 1,492 533.14 1.899 1.721 2.095 <0.001 14 30.19 33 11.79 2.257 1.195 4.265 0.012
Heart disease 557 1,272.26 1,484 563.44 1.890 1.713 2.085 <0.001 14 31.98 32 12.15 2.320 1.229 4.385 <0.001
CKD 559 1,226.09 1,487 544.84 1.883 1.707 2.078 <0.001 14 30.71 32 11.72 2.309 1.222 4.363 <0.001
Season
Spring 128 1,279.80 368 572.93 1.869 1.694 2.062 <0.001 4 39.99 9 14.01 2.516 1.332 4.755 <0.001
Summer 153 1,275.16 379 525.13 2.032 1.842 2.242 <0.001 1 8.33 9 12.47 0.589 0.312 1.113 0.413
Autumn 163 1,167.24 375 472.75 2.066 1.873 2.280 <0.001 3 21.48 8 10.09 1.878 0.994 3.549 0.058
Winter 117 1,117.57 370 573.81 1.630 1.477 1.798 <0.001 6 57.31 7 10.86 4.654 2.464 8.795 <0.001
Urbanization level
1 (The highest) 178 1,242.98 489 554.34 1.877 1.701 2.070 <0.001 5 34.92 11 12.47 2.468 1.307 4.665 <0.001
2 269 1,286.41 684 559.40 1.925 1.744 2.123 <0.001 3 14.35 11 9.00 1.406 0.744 2.657 0.632
3 51 1,079.30 112 420.19 2.150 1.948 2.372 <0.001 1 21.16 4 15.01 1.243 0.658 2.349 0.481
4 (The lowest) 63 972.66 207 480.65 1.694 1.535 1.868 <0.001 5 77.20 7 16.25 4.187 2.217 7.912 <0.001
Level of care
Hospital center 179 1,313.51 502 580.05 1.895 1.718 2.091 <0.001 3 22.01 5 5.78 3.359 1.779 6.348 <0.001
Regional hospital 233 1,172.03 540 494.49 1.984 1.798 2.188 <0.001 4 20.12 16 14.65 1.211 0.641 2.288 0.682
Local hospital 149 1,152.72 450 532.79 1.811 1.641 1.998 <0.001 7 54.15 12 14.21 3.360 1.779 6.350 <0.001

PYs = Person-years; Rate: per 105 PYs; Adjusted HR = Adjusted Hazard ratio: Adjusted for the variables listed in Table 3.; CI = Confidence interval