Table 3. Sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic odds ratio of 37 algorithms applicable to at least one case or control patient.
| Algorithm No. | TP | FN | Weighted FP | (Net FP) | Weighted TN | (Net TN) | Sensitivity | (95% CI) | Specificity | (95% CI) | PPV | (95% CI) | NPV | (95% CI) | DOR | (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A02 | 7 | 6 | 14.72 | (1) | 1457.28 | (99) | 53.9 | (29.1–76.8) | 99.0 | (98.4–99.4) | 32.2 | (16.6–53.2) | 99.6 | (99.1–99.8) | 115.50 | (34.61–385.49) |
| A09 | 1 | 12 | 0 | (0) | 1472.00 | (100) | 7.7 | (1.4–33.3) | 100.0 | (99.7–100.0) | 100.0 | (20.7–100.0) | 99.2 | (98.6–99.5) | 353.40 | (13.72–9102.13) |
| A10 | 0 | 13 | 14.72 | (1) | 1457.28 | (99) | 0.0 | (0.0–22.8) | 99.0 | (98.4–99.4) | 0.0 | (0.0–20.7) | 99.1 | (98.5–99.5) | 3.55 | (0.20–62.41) |
| B01 | 1 | 12 | 0 | (0) | 1472.00 | (100) | 7.7 | (1.4–33.3) | 100.0 | (99.7–100.0) | 100.0 | (20.7–100.0) | 99.2 | (98.6–99.5) | 353.40 | (13.72–9102.13) |
| B02 | 9 | 4 | 14.72 | (1) | 1457.28 | (99) | 69.2 | (42.4–87.3) | 99.0 | (98.4–99.4) | 37.9 | (21.4–57.8) | 99.7 | (99.3–99.9) | 222.75 | (61.63–805.03) |
| B04 | 1 | 12 | 14.72 | (1) | 1457.28 | (99) | 7.7 | (1.4–33.3) | 99.0 | (98.4–99.4) | 6.4 | (1.1–28.7) | 99.2 | (98.6–99.5) | 8.25 | (1.01–67.61) |
| B06 | 1 | 12 | 14.72 | (1) | 1457.28 | (99) | 7.7 | (1.4–33.3) | 99.0 | (98.4–99.4) | 6.4 | (1.1–28.7) | 99.2 | (98.6–99.5) | 8.25 | (1.01–67.61) |
| B07 | 0 | 13 | 14.72 | (1) | 1457.28 | (99) | 0.0 | (0.0–22.8) | 99.0 | (98.4–99.4) | 0.0 | (0.0–20.7) | 99.1 | (98.5–99.5) | 3.55 | (0.20–62.41) |
| B08 | 0 | 13 | 29.44 | (2) | 1442.56 | (98) | 0.0 | (0.0–22.8) | 98.0 | (97.2–98.6) | 0.0 | (0.0–11.5) | 99.1 | (98.5–99.5) | 1.79 | (0.10–30.73) |
| B09 | 1 | 12 | 0 | (0) | 1472.00 | (100) | 7.7 | (1.4–33.3) | 100.0 | (99.7–100.0) | 100.0 | (20.7–100.0) | 99.2 | (98.6–99.5) | 353.40 | (13.72–9102.13) |
| B10 | 0 | 13 | 14.72 | (1) | 1457.28 | (99) | 0.0 | (0.0–22.8) | 99.0 | (98.4–99.4) | 0.0 | (0.0–20.7) | 99.1 | (98.5–99.5) | 3.55 | (0.20–62.41) |
| B12 | 0 | 13 | 44.16 | (3) | 1427.84 | (97) | 0.0 | (0.0–22.8) | 97.0 | (96.0–97.8) | 0.0 | (0.0–8.0) | 99.1 | (98.5–99.5) | 1.18 | (0.07–20.24) |
| B13 | 0 | 13 | 14.72 | (1) | 1457.28 | (99) | 0.0 | (0.0–22.8) | 99.0 | (98.4–99.4) | 0.0 | (0.0–20.7) | 99.1 | (98.5–99.5) | 3.55 | (0.20–62.41) |
| B14 | 0 | 13 | 14.72 | (1) | 1457.28 | (99) | 0.0 | (0.0–22.8) | 99.0 | (98.4–99.4) | 0.0 | (0.0–20.7) | 99.1 | (98.5–99.5) | 3.55 | (0.20–62.41) |
| B15 | 0 | 13 | 73.60 | (5) | 1398.40 | (95) | 0.0 | (0.0–22.8) | 95.0 | (93.8–96.0) | 0.0 | (0.0–5.0) | 99.1 | (98.4–99.5) | 0.70 | (0.04–11.88) |
| B16 | 0 | 13 | 323.84 | (22) | 1148.16 | (78) | 0.0 | (0.0–22.8) | 78.0 | (75.8–80.0) | 0.0 | (0.0–1.2) | 98.9 | (98.1–99.3) | 0.13 | (0.01–2.21) |
| B20 | 0 | 13 | 14.72 | (1) | 1457.28 | (99) | 0.0 | (0.0–22.8) | 99.0 | (98.4–99.4) | 0.0 | (0.0–20.7) | 99.1 | (98.5–99.5) | 3.55 | (0.20–62.41) |
| B24 | 0 | 13 | 73.60 | (5) | 1398.40 | (95) | 0.0 | (0.0–22.8) | 95.0 | (93.8–96.0) | 0.0 | (0.0–5.0) | 99.1 | (98.4–99.5) | 0.70 | (0.04–11.88) |
| B28 | 0 | 13 | 14.72 | (1) | 1457.28 | (99) | 0.0 | (0.0–22.8) | 99.0 | (98.4–99.4) | 0.0 | (0.0–20.7) | 99.1 | (98.5–99.5) | 3.55 | (0.20–62.41) |
| B30 | 0 | 13 | 14.72 | (1) | 1457.28 | (99) | 0.0 | (0.0–22.8) | 99.0 | (98.4–99.4) | 0.0 | (0.0–20.7) | 99.1 | (98.5–99.5) | 3.55 | (0.20–62.41) |
| B31 | 0 | 13 | 73.60 | (5) | 1398.40 | (95) | 0.0 | (0.0–22.8) | 95.0 | (93.8–96.0) | 0.0 | (0.0–5.0) | 99.1 | (98.4–99.5) | 0.70 | (0.04–11.88) |
| B32 | 0 | 13 | 706.56 | (48) | 765.44 | (52) | 0.0 | (0.0–22.8) | 52.0 | (49.5–54.5) | 0.0 | (0.0–0.5) | 98.3 | (97.2–99.0) | 0.04 | (0.00–0.68) |
| C02 | 7 | 6 | 14.72 | (1) | 1457.28 | (99) | 53.9 | (29.1–76.8) | 99.0 | (98.4–99.4) | 32.2 | (16.6–53.2) | 99.6 | (99.1–99.8) | 115.50 | (34.61–385.49) |
| C10 | 1 | 12 | 14.72 | (1) | 1457.28 | (99) | 7.7 | (1.4–33.3) | 99.0 | (98.4–99.4) | 6.4 | (1.1–28.7) | 99.2 | (98.6–99.5) | 8.25 | (1.01–67.61) |
| D02 | 10 | 3 | 14.72 | (1) | 1457.28 | (99) | 76.9 | (49.7–91.8) | 99.0 | (98.4–99.4) | 40.5 | (23.7–59.8) | 99.8 | (99.4–99.9) | 330.00 | (82.31–1323.06) |
| D04 | 1 | 12 | 14.72 | (1) | 1457.28 | (99) | 7.7 | (1.4–33.3) | 99.0 | (98.4–99.4) | 6.4 | (1.1–28.7) | 99.2 | (98.6–99.5) | 8.25 | (1.01–67.61) |
| D06 | 1 | 12 | 14.72 | (1) | 1457.28 | (99) | 7.7 | (1.4–33.3) | 99.0 | (98.4–99.4) | 6.4 | (1.1–28.7) | 99.2 | (98.6–99.5) | 8.25 | (1.01–67.61) |
| D08 | 0 | 13 | 44.16 | (3) | 1427.84 | (97) | 0.0 | (0.0–22.8) | 97.0 | (96.0–97.8) | 0.0 | (0.0–8.0) | 99.1 | (98.5–99.5) | 1.18 | (0.07–20.24) |
| D10 | 1 | 12 | 14.72 | (1) | 1457.28 | (99) | 7.7 | (1.4–33.3) | 99.0 | (98.4–99.4) | 6.4 | (1.1–28.7) | 99.2 | (98.6–99.5) | 8.25 | (1.01–67.61) |
| D12 | 0 | 13 | 44.16 | (3) | 1427.84 | (97) | 0.0 | (0.0–22.8) | 97.0 | (96.0–97.8) | 0.0 | (0.0–8.0) | 99.1 | (98.5–99.5) | 1.18 | (0.07–20.24) |
| D14 | 0 | 13 | 29.44 | (2) | 1442.56 | (98) | 0.0 | (0.0–22.8) | 98.0 | (97.2–98.6) | 0.0 | (0.0–11.5) | 99.1 | (98.5–99.5) | 1.79 | (0.10–30.73) |
| D16 | 0 | 13 | 397.44 | (27) | 1074.56 | (73) | 0.0 | (0.0–22.8) | 73.0 | (70.7–75.2) | 0.0 | (0.0–1.0) | 98.8 | (98.0–99.3) | 0.10 | (0.01–1.69) |
| D20 | 0 | 13 | 14.72 | (1) | 1457.28 | (99) | 0.0 | (0.0–22.8) | 99.0 | (98.4–99.4) | 0.0 | (0.0–20.7) | 99.1 | (98.5–99.5) | 3.55 | (0.20–62.41) |
| D24 | 0 | 13 | 73.60 | (5) | 1398.40 | (95) | 0.0 | (0.0–22.8) | 95.0 | (93.8–96.0) | 0.0 | (0.0–5.0) | 99.1 | (98.4–99.5) | 0.70 | (0.04–11.88) |
| D28 | 0 | 13 | 14.72 | (1) | 1457.28 | (99) | 0.0 | (0.0–22.8) | 99.0 | (98.4–99.4) | 0.0 | (0.0–20.7) | 99.1 | (98.5–99.5) | 3.55 | (0.20–62.41) |
| D30 | 0 | 13 | 14.72 | (1) | 1457.28 | (99) | 0.0 | (0.0–22.8) | 99.0 | (98.4–99.4) | 0.0 | (0.0–20.7) | 99.1 | (98.5–99.5) | 3.55 | (0.20–62.41) |
| D32 | 0 | 13 | 780.16 | (53) | 691.84 | (47) | 0.0 | (0.0–22.8) | 47.0 | (44.5–49.6) | 0.0 | (0.0–0.5) | 98.2 | (96.9–98.9) | 0.03 | (0.00–0.55) |
TP, true positive; FP, false positive; TN, true negative; FN, false negative; PPV, positive predictive value; NPV, negative predictive value; DOR, diagnostic odds ratio.