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Pharmacokinetic Parameters for 12 in Male Sprague—Dawley Rats
| parameter | plasma | brain |
|---|---|---|
| t1/2 (h) | 30.7 | 57.2 |
| Cmax (ng/mL or ng/g) | 333 | 239 |
| Tmax (h) | 1 | 4 |
| clearance (mL/h/kg) | 2625 | 234 |
| AUClast (h·ng/mL or h·ng/g) | 1864 | 18765 |
| AUCtotal (h·ng/mL or h·ng/g) | 1905 | 21400 |
| ratio of brain/plasma AUClast | 10.07 | 10.07 |
