Appendix 1—figure 1. Scheme of the ‘Viroplasm Direct Least Square Fitting Circumference’ algorithm (VPs-DLSFC).

SRM) Complete SRM image; A) Manual pre-segmentation step, an expert selects and isolates each viroplasm as a single image; B) Fit a circumference to the reference protein through the algorithm DLSFC; C) The center of the reference protein is taken as the center of the accompanying protein, and then the radius of the adjust circumference for this second protein is computed.