Appendix 1—table 2. Two-sample Mann-Whitney hypothesis test between $a$ (major semi-axis of the ellipse ) and $r$ (circumference radius).

H0(H1): The radii of the circumferences and the values of the major semi-axis of the ellipses came from the same distribution function (different). Column 1: W represent the distribution value of the statistical test; Difference is the estimation of the location parameter (median difference between $a$ and $r$); P. Value is the p-value of the test; C. Interval is the 95% confidence interval. For each one of the nine viral elements combinations, we carry up the hyphotesis test taking into account NSP2 independenly in each combination, just for the semi-major axis this table shows the results of 18 Mann-Whitney hypothesis tests. More information about this test is available in Mann and Whitney (1947) and Hollander et al. (2013).

	Proteins Combinations
	NSP2/NSP4		NSP2/NSP5		NSP2/VP1		NSP2/VP2
Statistics	NSP2	NSP4	NSP2	NSP5	NSP2	VP1	NSP2	VP2
W	900	902	1426	1415	559	539	174	184
Difference	0.0352	0.03369	0.0358	0.0357	0.0213	0.026	0.0529	0.0512
P. Value	0.1233	0.127	0.091	0.08025	0.1776	0.117	0.1137	0.1789
95% CI	[−0.082, 0.011]	[−0.08,0.013]	[−0.086, 0.007]	[−0.08,0.006]	[−0.054,0.012]	[−0.057, 0.006]	[−0.1168,0.0204]	[-0.15, 0.028]
	NSP2/VP4		NSP2/VP6		NSP2/VP7-Tri		NSP2/VP7-Mon
Statistics	NSP2	VP4	NSP2	VP6	NSP2	VP7-Tri	NSP2	VP7-Mon
W	771	760	119	134	1425	1421	551	528
Difference	0.0264	0.0221	0.0393	0.031	0.0301	0.032	0.0487	0.055
P. Value	0.1012	0.0833	0.0747	0.1814	0.1567	0.1503	0.1513	0.092
95% CI	[−0.0549, 0.0044]	[−0.051,0.003]	[−0.0909,0.0067]	[−0.103,0.034]	[−0.0675,0.0105]	[−0.073, 0.014]	[−0.1165,0.0221]	[−0.119,0.01]