Appendix 1—table 5. Two-sample Mann-Whitney hypothesis test, considering as variables the radii of NSP2 in contrast with the radii of the others seven viral proteins.

Under the null hypothesis, both samples come from the same distribution (H0: true location is equal to zero), while the alternative hypothesis (H1: true location is not equal to zero) establishes that exist a difference between the median of the distributions. Protein: Name of the viral element compared with NSP2; W: value of the Mann-Whitney statistical hypothesis test; Difference: Estimation of the location parameter (median difference between the radii of NSP2 and the radii of the other viral element); C. Interval: 95% confidence interval; P. Value: p-value of the test.

Protein	W	Difference in location	95% CI	p-value
NSP5	1327	−0.048972049	[−0.086040620,–0.01563190]	${\displaystyle 2.968772\times {10}^{-3}}$
NSP4	4711	−0.003348142	[−0.032696239, 0.02632726]	${\displaystyle 8.197094\times {10}^{-1}}$
VP1	1699	0.044239569	[0.012214263, 0.07804365]	${\displaystyle 7.728702\times {10}^{-3}}$
VP2	3557	0.040956503	[0.010802771, 0.06990018]	${\displaystyle 5.166044\times {10}^{-3}}$
VP6	4316	0.063282322	[0.032020596, 0.09793399]	${\displaystyle 1.407904\times {10}^{-4}}$
VP4	2637	0.150597251	[0.115162890, 0.18499337]	${\displaystyle 1.824306\times {10}^{-11}}$
VP7-Mon	4280	0.392334895	[0.350192949, 0.43852366]	${\displaystyle 1.130338\times {10}^{-21}}$
VP7-Tri	1814	0.400145108	[0.324450625, 0.46457274]	${\displaystyle 1.611397\times {10}^{-14}}$