Appendix 1—table 6. Results and validation of the linear regression models.

NSP2 was considered as the independent variable and the other viral elements as the dependent variable (see Equation (25)). The slope and standard error for each regression model (Column 2 and 3) were computed in accordance with the Equation (26) and (28) respectively. The t-value of the t-Student distribution function with N-1 degrees of freedom are in Column 4 (see Appendix 1 Section – Linear Regression Model– for details). The p-value for each linear regression model are shows in Column five and were measure as was described in (Equation (29)) and (Equation (30)). Finally, the RSE and the $R^2$ summarize the adjustment of the data through the proposed lineal models. As was advised, the RSE (Column 6) is a fit measure of the linear model to the data (see Equation (27)). The ‘% Error’ is the average error in the prediction and it is computed as: $100\times RSE/\beta$, while the $100\times R^2$ is the percent of the data variance that it is explained by the model (see Equation (32)).

Model	Slope (β)	Std.error ${\displaystyle \left({\sigma }_{\hat{\beta }}^2\right)}$	t-value	p-value	RSE	% Error	R2
${\displaystyle NSP5={\beta }_{NSP5}\times NSP2}$	0.8667494	0.017947738	48.29296	2.550154 × 10−50	0.07	8%	0.974
${\displaystyle NSP4={\beta }_{NSP4}\times NSP2}$	0.9911517	0.006973701	142.12708	2.271571 × 10−114	0.035	3.5%	0.995
${\displaystyle VP2={\beta }_{VP2}\times NSP2}$	1.1243931	0.014817985	75.88030	6.242800 × 10−72	0.04	3.5%	0.987
${\displaystyle VP1={\beta }_{VP1}\times NSP2}$	1.1506138	0.019069730	60.33718	2.238867 × 10−48	0.044	3.8%	0.986
${\displaystyle VP6={\beta }_{VP6}\times NSP2}$	1.1806335	0.011218918	105.23595	1.087989 × 10−86	0.038	3.2%	0.992
${\displaystyle VP4={\beta }_{VP4}\times NSP2}$	1.3887083	0.024319983	57.10153	5.757257 × 10−50	0.07	5%	0.983
${\displaystyle \text{VP7-Mon}={\beta }_{\text{VP7-Mon}}\times NSP2}$	1.9407204	0.040354225	48.09212	1.560719 × 10−52	0.142	7.3%	0.972
${\displaystyle \text{VP7-Tri}={\beta }_{\text{VP7-Tri}}\times NSP2}$	1.9416542	0.054656327	35.52478	5.778910 × 10−33	0.153	7.8%	0.967