Figure 1. Distributions of relative fitness effects of gtsB point mutations in low glucose media.

(A) Counts of nonsynonymous (blue; n = 71) and synonymous (red; n = 39) mutations display a wide range of fitness effects, with ticks under the bars indicating the relative fitness values of nonsense mutations. Dashed and dotted lines show the mean relative fitness of the wild type (WT) competed against the marked competitor. (B) The DFE of beneficial-effect mutations (proportions; pooled synonymous and nonsynonymous samples, n = 55) is fit by a κ value of −0.35, which corresponds to the Weibull domain of attraction of the Generalised Pareto Distribution. On this normalised histogram (total area = 1), relative fitness values are shifted to the smallest observed value and expressed as selection coefficients. See Figure 1—source data 1.