Figure 3:

Mean CE T1-weighted intensity, normalized by mean muscle intensity, in femur and tibia VOIs. (A) Mean CE T1-weighted normalized intensity in non-tumor bearing (NT) mice, untreated tumor bearing mice at weeks 3 (U3) and 4 (U4), and treated tumor-bearing mice at weeks 3–4 (MT) and 5–6 (ET). (B) Mean CE, T1-weighted normalized intensity relative to week 2 baseline for each animal (%difference = (Time-point Mean – Baseline Mean)/(Baseline Mean)). Statistical significance was calculated using a one-way ANOVA with the Tukey multiple comparisons test performed individually on the tibia and femur VOIs (*p < 0.05, **p < 0.01, ***p < 0.001; closed line indicates comparison between two groups, open-ended line indicates statistical significance between one group against all other included groups). Whiskers indicate 5–95% confidence intervals.