Skip to main content
. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Neurosci Biobehav Rev. 2019 Jun 15;103:50–59. doi: 10.1016/j.neubiorev.2019.06.010

Figure 3. CRF1 signaling in the caudal dmPFC impairs working memory.

Figure 3.

In male rats, local PFC CRF release and subsequent activation of CRF1 receptors coupled to PKA impairs performance in a delayed alternation test of spatial working memory. These actions are associated with a robust degradation in delay-related activity of PFC pyramidal neurons in animals undergoing working memory testing.