Table 1:

New drug Targets of potential interest in AUD.

Target	Drug	Drug Activity	Key Finding	Reference
PPARγ	Pioglitazone	Agonism	Reduce SA Reduce stress-induced reinstatement	(Stopponi et al., 2011)
PPARα	Fenofibrate Tesaglitazar Bezafibrate	Agonism	Reduce SA	(Blednov et al., 2015)
PDE4	Rolipram	Inhibition	Reduce SA	(Wen et al., 2012)
PDE10	TP-10	Inhibition	Reduce SA	(Logrip et al., 2014)
CRF1R	CRA1000 MTIP MPZP LWH-63 Antalarmin KO mice D-Phe-CRF(12–41)	Antagonism	Reduce SA Reduce withdrawal	(Chu et al., 2007; Funk et al., 2007; Gehlert et al., 2007; Gilpin et al., 2008; Knapp et al., 2004; Richardson et al., 2008; Sabino et al., 2006; Sommer et al., 2008)
NOP	N/OFQ Ro 64–6198 LY2940094 KO rats	Agonism Antagonism	Reduce CPP Reduce SA Reduce withdrawal	(Ciccocioppo et al., 2004; Ciccocioppo et al., 1999; Economidou et al., 2011; Kallupi et al., 2017; Kuzmin et al., 2003; Martin-Fardon et al., 2000; Rorick-Kehn et al., 2016)
OX1	SB-334867		Reduce cue- and stress-induced reinstatement	(Lawrence et al., 2006; Richards et al., 2008)
NPSR	NPS	Agonism	Increase cue-induced reinstatement Reduce SA in alcohol-preferring rats	(Cannella et al., 2009; Cannella et al., 2016; Ruggeri et al., 2010)
NK1R	LY686017 L822429 KO mice	Antagonism	Reduce SA Reduce CPP Reduce stress-induced reinstatement	(Ayanwuyi et al., 2015; George et al., 2008; Schank et al., 2011; Thorsell et al., 2010)
mAChR subtype 5	ML375	NAM	Reduce SA Reduce cue-induced reinstatement	(Berizzi et al., 2018)

SA= Self Administration; CPP=Conditioned Place Preference; NAM= Negative Allosteric Modulator.