Figure 4.

WT rats recover from SPS within 8 weeks, while effects on anxiety-like behavior and CA1 volume persist in TK rats. A) Timeline showing experimental paradigm. B,C) Stressed TK rats show increased anxiety-like behavior, but WT rats no longer show effects of stress in the elevated plus-maze (B) and novelty-suppressed feeding (C) tests. D) Stress decreased preference for a displaced object in rats with and without adult neurogenesis. E,F) SPS had little impact on contextual freezing or extinction (E) or on spontaneous reinstatement of freezing (F). G-J) Stress had no effect on overall hippocampal volume (G) or dentate gyrus volume (H), but increased volume in CA3 (I). Stressed TK rats showed reduced volume in ventral CA1, while stressed WT rats had normalized to control levels (J). K,L) All groups had similarly low levels of serum corticosterone after freely exploring the elevated plus-maze (K), but stressed TK rats had elevated serum corticosterone when confined on an open arm (L). * p < .05 compared to control or WT, @ p < .10 compared to control, # p < .05 in one-sample t-test compared to 0.