Figure 3.

Example of relapsing-remitting multiple sclerosis patients with very high anti-EBNA-1 titer and presence of T1-hypointensities

The patient had relatively low disease duration of 10 years, EDSS score of 3.5 and was on natalizumab treatment. At the time of serum sample examination, the patient presented with abnormally high titer of anti-EBNA-1 antibodies. The corresponding lesioned MRI features include 11 T1-hypointense lesions with total volume of 12.2ml and 12 T2-hyperintense lesions with total volume of 22.4ml. EDSS – Expanded Disability Status Scale, DMT – disease modifying therapy, EBNA-1 – Epstein Barr nuclear antigen-1.